CANDIDATE GENES INVOLVED IN THE BIOSYNTHESIS OF TRITERPENOID SAPONINS IN PLATYCODON GRANDIFLORUM IDENTIFIED BY TRANSCRIPTOME ANALYSIS

Candidate genes involved in the biosynthesis of triterpenoid saponins in Platycodon grandiflorum identified by transcriptome analysis

Background: Platycodon grandiflorum is the only species in the genus Walking Sticks Platycodon of the family Campanulaceae, which has been traditionally used as a medicinal plant for its lung-heat-clearing, antitussive, and expectorant properties in China, Japanese and Korean.Oleanane-type triterpenoid saponins were the main chemical components of

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Effects of PCSK9 inhibitors on coronary microcirculation, inflammation and cardiac function in patients with CHD after PCI: a protocol for systematic review and meta-analysis

Introduction Coronary heart disease (CHD) is one of the common cardiovascular diseases that seriously jeopardise human health, and endothelial inflammation and dyslipidaemia are the initiating links leading to its occurrence.Percutaneous coronary intervention (PCI) is one of the most effective surgical treatments for CHD with narrowed or blocked bl

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Bounded and categorized: targeting data assimilation for sea ice fractional coverage and nonnegative quantities in a single-column multi-category sea ice model

A rigorous exploration of the sea ice data assimilation (DA) problem using a framework specifically developed for rapid, interpretable hypothesis testing is presented.In many applications, DA is implemented to constrain a modeled estimate of a state with observations.The sea ice DA application is complicated by the wide range of spatiotemporal scal

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